Sodium Rifamycin S (CAS 133956-65-7)
High-Purity Pharmaceutical Intermediate for Advanced Antibiotic Synthesis
Welcome to the premier destination for high-quality Sodium Rifamycin S (CAS No. 133956-65-7). Manufactured by Zhengzhou Minzhong Pharmaceutical Co., Ltd., a leader in the global antibiotic API market, our product stands as a critical building block for the synthesis of next-generation antibiotics, including Rifaximin.
Product Overview
Sodium Rifamycin S is the sodium salt form of Rifamycin S, a pivotal compound in the ansamycin family of antibiotics. It is primarily utilized as a sophisticated intermediate in the pharmaceutical industry for the synthesis of downstream Active Pharmaceutical Ingredients (APIs). Its high reactivity and stability profile make it an essential precursor for manufacturing broad-spectrum antibiotics used to treat gastrointestinal and systemic infections.
Key Chemical Identity
- Chemical Name: Sodium Rifamycin S (Rifamycin S Sodium Salt)
- CAS Number: 133956-65-7
- Molecular Formula: C37H45NO12·Na
- Molecular Weight: ~717.7 g/mol (approx)
- Synonyms: Rifamycin S Sodium; 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-rifamycin Sodium Salt
Technical Specifications
At Zhengzhou Minzhong Pharmaceutical Co., Ltd., we adhere to strict GMP (Good Manufacturing Practice) standards to ensure batch-to-batch consistency.
| Property | Specification |
|---|---|
| Appearance | Reddish-brown to orange crystalline powder |
| Assay (HPLC) | ≥ 98.0% |
| Solubility | Soluble in water and methanol; sparingly soluble in ethanol |
| Identification | IR, HPLC matches standard |
| Moisture | ≤ 2.0% |
| Storage | Preserve in tight, light-resistant containers at controlled room temperature |
(Note: Detailed Certificate of Analysis (COA) is available upon request.)
Key Applications & Uses
Sodium Rifamycin S is not just a chemical compound; it is the backbone of modern antibiotic production.
1. Key Intermediate for Rifaximin
The primary industrial application of CAS 133956-65-7 is as a precursor in the synthesis of Rifaximin, a non-systemic antibiotic used to treat traveler’s diarrhea and hepatic encephalopathy. High-purity Sodium Rifamycin S ensures higher yield and fewer impurities in the final Rifaximin API.
2. Pharmaceutical Research & Development
It is widely used in R&D sectors for studying rifamycin derivatives, investigating mechanism-of-action in RNA polymerase inhibition, and developing new semi-synthetic antibiotics.
3. Antimicrobial Activity
Like its parent compound, Sodium Rifamycin S exhibits potent antibacterial properties against Gram-positive bacteria, making it a valuable subject for formulation studies.
Why Choose Zhengzhou Minzhong Pharmaceutical Co., Ltd?
Established in 1994, Zhengzhou Minzhong Pharmaceutical Co., Ltd. has evolved into a comprehensive modern enterprise integrating R&D, production, and sales.
🏭 Decade of Excellence
With nearly 30 years of experience, we are one of China’s most established manufacturers of Rifamycin series products. Our facility in the Zhengzhou-Kaifeng Industry Zone is equipped with advanced fermentation and synthesis capabilities.
✅ Quality Assurance
We operate under a rigorous quality management system.
- GMP Compliance: Our production lines meet global Good Manufacturing Practice standards.
- Advanced Testing: Equipped with HP (Hewlett-Packard) micro-electronic inspection and analysis instruments.
- Collaboration: We maintain long-term technical cooperation with the Sichuan Antibiotics Research Institute and Zhengzhou University Institute of Pharmacy.
🌍 Global Reach
Our products, including Rifamycin Sodium and Rifampicin, hold domestic approval numbers and DMFs. We successfully export to over 88 sales regions worldwide, building a reputation for reliability and excellence.
Frequently Asked Questions (FAQ)
Q: What is the difference between Rifamycin Sodium and Sodium Rifamycin S? A: While often sounded similar, they refer to different chemical states or oxidation levels. “Rifamycin Sodium” typically refers to Rifamycin SV Sodium (CAS 14897-39-3), whereas Sodium Rifamycin S (CAS 133956-65-7) is the salt of the oxidized Rifamycin S form. We supply both to meet specific synthesis needs.
Q: Can you provide samples for validation? A: Yes, we support our partners with samples for quality testing and validation. Please contact our sales team for arrangements.
Q: What is the packaging standard? A: Standard packaging includes 5kg/tin or 25kg/drum, ensuring stability during transport. Custom packaging solutions are available upon request.
Contact Us
Ready to secure a reliable supply of Sodium Rifamycin S (CAS 133956-65-7)? Partner with Zhengzhou Minzhong Pharmaceutical Co., Ltd. for competitive pricing and uncompromised quality.