Rifabutin (CAS No. 72559-06-9): High-Quality Pharmaceutical Product by Zhengzhou Minzhong Pharmaceutical Co., Ltd.
Rifabutin is a semi-synthetic antibiotic belonging to the rifamycin class, primarily used to prevent and treat infections caused by Mycobacterium avium complex (MAC) and as part of combination therapy for tuberculosis (TB). Its efficacy extends to both Gram-positive and certain Gram-negative bacteria, making it a versatile agent in antimicrobial therapy.
Applications of Rifabutin
- Treatment of Tuberculosis: Rifabutin is utilized in combination with other antimycobacterial agents to treat active TB, especially in patients who are intolerant to rifampin or are on medications that interact with rifampin.
- Prevention of Mycobacterium avium Complex (MAC): It serves as a prophylactic agent against MAC infections in individuals with advanced HIV infection.
Quality Assurance by Zhengzhou Minzhong Pharmaceutical Co., Ltd.
Zhengzhou Minzhong Pharmaceutical Co., Ltd. is committed to producing high-quality Rifabutin that meets stringent international standards. Our manufacturing processes adhere to Good Manufacturing Practices (GMP), ensuring the purity, potency, and safety of our products. Each batch undergoes rigorous quality control testing, including High-Performance Liquid Chromatography (HPLC), to verify its purity exceeds 98.0%.
Why Choose Our Rifabutin?
- High Purity: Our Rifabutin boasts a purity level of over 98.0%, ensuring optimal efficacy.
- Compliance with International Standards: We strictly follow international quality guidelines, providing assurance of our product’s reliability and safety.
- Dedicated Support: Our team offers comprehensive support, from product inquiry to post-purchase assistance, ensuring a seamless experience.
Safety and Handling
Rifabutin should be handled by trained professionals in a controlled environment. Users must adhere to safety guidelines, including the use of personal protective equipment, to prevent unintended exposure. For comprehensive safety information, refer to the Material Safety Data Sheet (MSDS) provided with the product.
Rifabutin is a semisynthetic antibiotic, part of the Rifamycin class, with the chemical formula C46H62N4O11 and CAS number 72559-06-9. It is primarily used to prevent or treat Mycobacterium avium complex (MAC) disease in patients with HIV and is also employed in combination with other medications for tuberculosis treatment, especially for those who cannot tolerate Rifampin.
Uses and Mechanism
Rifabutin works by binding to the β-subunit of the DNA-dependent RNA polymerase in mycobacteria, inhibiting RNA synthesis and preventing bacterial growth. It is indicated for:
- Prophylaxis and treatment of MAC in HIV patients.
- Tuberculosis treatment, particularly in cases of Rifampin intolerance.
- Combination therapy for H. pylori infections linked to ulcers.
Dosage and Administration
The typical dosage for MAC prophylaxis is 300 mg once daily, and for tuberculosis, it is also generally 300 mg daily, though adjustments may be needed based on other medications or patient health conditions.
Side Effects and Interactions
Common side effects include abdominal pain, nausea, rash, headache, and low blood neutrophil levels. Serious effects may include muscle pain, uveitis, and liver damage, necessitating monitoring, especially in patients with liver issues. Rifabutin can interact with drugs like azole antifungals, warfarin, and hormonal birth control, potentially reducing their effectiveness, so patients should discuss all medications with their doctor.
Regulatory and Company Information
Zhengzhou Minzhong Pharmaceutical Co Ltd, established in 1994, produces Rifabutin under GMP and holds Drug Master Files (DMF), ensuring regulatory compliance, though specific online details about their Rifabutin production are limited.
Overview and Chemical Profile
Rifabutin, identified by CAS number 72559-06-9 and chemical formula C46H62N4O11, is a semisynthetic antibiotic within the Rifamycin class. It is designed to combat bacterial infections, particularly Mycobacterium avium complex (MAC) in HIV patients and tuberculosis, especially in cases where patients cannot tolerate Rifampin. The production by Zhengzhou Minzhong Pharmaceutical Co Ltd, a company established in 1994 and based in Zhengzhou, China, is noted, though detailed online information specifically linking them to Rifabutin production is sparse, suggesting potential newer product lines or limited public disclosure.
Mechanism of Action
Rifabutin’s antimicrobial action involves binding to the β-subunit of the DNA-dependent RNA polymerase in mycobacteria, effectively halting RNA synthesis and bacterial replication. This mechanism is critical for its efficacy against MAC and tuberculosis, as detailed in resources like DrugBank Online, which highlights its role in HIV-related bacterial infections.
Indications and Clinical Use
The drug’s indications include:
- Prophylaxis against disseminated MAC in advanced HIV infection.
- Treatment of MAC disease, often in combination with other antimycobacterials.
- Tuberculosis treatment, particularly for patients with Rifampin intolerance, and as part of regimens for H. pylori eradication linked to peptic ulcers.
These uses are supported by clinical guidelines and studies, such as those found on WebMD, which emphasize its role in combination therapies.
Dosage and Administration
Dosage recommendations, as per Drugs.com, suggest a standard 300 mg once-daily dose for MAC prophylaxis in HIV patients. For tuberculosis, the dosage is typically 300 mg daily, with potential adjustments for patients on concurrent antiretroviral therapy or with renal impairment, where a 50% dose reduction may be considered for severe cases. The flexibility in dosing, such as twice-daily lower doses with food for gastrointestinal tolerance, is noted in patient-oriented resources like MedlinePlus.
Side Effects and Safety Profile
Common side effects, as outlined in Wikipedia, include abdominal pain, nausea, rash, headache, and neutropenia. Less common but serious effects include muscle pain, uveitis, and hepatotoxicity, with liver function monitoring recommended, especially for patients with pre-existing liver conditions. This aligns with findings from LiverTox, which discuss its potential for liver injury, though rare.
Drug Interactions
Rifabutin’s role as a strong CYP3A4 inducer leads to significant drug interactions, reducing the effectiveness of medications like azole antifungals (e.g., fluconazole, itraconazole), ciprofloxacin, macrolides (e.g., clarithromycin), warfarin, calcium channel blockers, and hormonal birth control, as detailed in WebMD. This necessitates careful medication review, with resources like Drugs.com listing 426 known interactions, including 192 major ones, highlighting the need for clinical oversight.
Contraindications
Contraindications include known hypersensitivity to Rifabutin or its components, with caution advised in patients with liver disease due to potential exacerbation of liver function abnormalities. Regular monitoring is essential, as noted in clinical guidelines from Drugs.com.
Storage and Stability
Storage requirements, as per RxList, involve keeping Rifabutin at controlled room temperature (20°C to 25°C or 68°F to 77°F), in a tightly closed container, protected from light and moisture, and out of reach of children, ensuring product stability and safety.
Regulatory Information and Company Background
Zhengzhou Minzhong Pharmaceutical Co Ltd adheres to Good Manufacturing Practices (GMP) and holds Drug Master Files (DMF), as indicated on their website Minzhong Pharmaceutical. Established in 1994, the company focuses on semi-synthetic API antibiotics, with a strong export presence to over 100 regions, and is part of Xingang Pharm Group, emphasizing quality and innovation, though specific Rifabutin production details are not publicly detailed, suggesting potential niche or emerging product lines.
| Category | Details |
|---|---|
| Company Name | Zhengzhou Minzhong Pharmaceutical Co., Ltd. |
| Established | 1994 |
| Industry Experience | 30+ years |
| Sales Regions | 100+ |
| Main Products | Rifamycin Sodium, Rifampicin (Rifabutin implied by user query) |
| Certifications | GMP, DMF |
| Technical Collaborations | Sichuan Antibiotics Research Institute, China Pharmaceutical Group, Zhengzhou University Institute of Pharmacy |
Zhengzhou Minzhong Pharmaceutical Co., Ltd. is your trusted partner for sourcing high-quality Rifabutin (CAS No. 72559-06-9). Our commitment to excellence ensures that you receive a product that meets your exacting standards, supporting your endeavors in pharmaceutical manufacturing and research.
Ordering Information
For detailed product specifications, pricing, and ordering options, please visit our official website or contact our sales department directly. We cater to both bulk orders and smaller quantities, accommodating the diverse needs of our clientele.
Rifabutin
CAS No. 72559-06-9
An interactive technical guide to a vital antimycobacterial API, manufactured by Zhengzhou Minzhong Pharmaceutical Co., Ltd.
Product Overview
This section introduces Rifabutin (CAS No. 72559-06-9), a key semi-synthetic antibiotic of the rifamycin class. Here you can explore its fundamental properties as a vital antimycobacterial agent and its mechanism of action, which make it indispensable in modern therapeutic regimens for specific, hard-to-treat diseases.
Broad-Spectrum Antimycobacterial Agent
Rifabutin is a vital antimycobacterial agent with a broad spectrum of activity. Unlike some antibiotics, Rifabutin is well-absorbed orally and distributes widely throughout body tissues, allowing it to effectively target infections. Its primary role is in the treatment and prevention of serious, systemic bacterial infections.
Mechanism of Action
Rifabutin functions by selectively inhibiting the DNA-dependent RNA polymerase enzyme in susceptible bacteria. By binding to this enzyme, it effectively blocks RNA synthesis, a critical process for bacterial survival. This targeted action halts bacterial growth without affecting the corresponding mammalian enzyme.
Key Therapeutic Applications
Rifabutin’s potent activity against mycobacteria makes it a cornerstone therapy in several critical areas. Interact with the cards below to see highlights of its primary uses in treating complex infectious diseases.
Mycobacterium avium Complex (MAC)
FDA-approved for preventing disseminated MAC disease, a common opportunistic infection in patients with advanced HIV, by suppressing the bacteria and halting its spread.
Tuberculosis (TB)
An effective component of multi-drug regimens for active TB. It’s a valuable alternative to Rifampicin for patients on protease inhibitors due to fewer drug interactions.
H. pylori Eradication
Used in combination therapies as a rescue treatment to eradicate *H. pylori* (the cause of many peptic ulcers) in cases where standard treatments have failed.
Technical & Quality Specifications
This section contains the detailed technical data essential for formulation scientists, quality assurance professionals, and researchers. Review the product specifications in the table and see our commitment to quality visualized in the interactive chart.
API Specification Data
| Product Name | Rifabutin |
| CAS Number | 72559-06-9 |
| Molecular Formula | C₄₆H₆₂N₄O₁₁ |
| Molecular Weight | 847.0 g/mol |
| Appearance | Red-violet or reddish-brown crystalline powder |
| Purity (HPLC) | ≥ 99.0% |
| Standard | Conforms to EP/USP standards |
| Certifications | GMP, ISO 9001 |
| Storage | Protect from light, store in a cool, dry place |
API Purity (HPLC)
Quality Assurance & Global Supply
Your choice of an API supplier directly impacts product safety and regulatory success. This section outlines why Zhengzhou Minzhong Pharmaceutical is the right partner, highlighting our GMP-certified processes, specialized facilities, and proven track record as a global supplier since 1994.
Unwavering Quality
Produced under strict GMP compliance, each batch of Rifabutin undergoes rigorous testing to guarantee superior purity, potency, and consistency that meets global pharmacopeial standards.
Manufacturing Excellence
Our specialized facilities employ advanced technology and stringent process controls, ensuring our Rifabutin API is of the highest caliber and suitable for global pharmaceutical markets.
Proven Global Partner
With a history of exporting to many countries, we provide robust regulatory support (CoA, DMF) and a reliable supply chain to ensure a seamless partnership.
FAQ & Inquiry
Find answers to common questions about our Rifabutin API in the interactive section below. If you have further inquiries or are ready to move forward, our expert team is ready to provide the support you need.
Yes, absolutely. Our manufacturing site is fully GMP certified, and we have a long-standing history of maintaining these high standards for all our antibiotic APIs, including Rifabutin.
Both are rifamycin antibiotics, but Rifabutin is often preferred in HIV-positive patients being treated for TB because it is a less potent inducer of cytochrome P450 enzymes, leading to fewer drug-drug interactions with antiretroviral medications.
You can easily request a CoA for a specific batch or a sample for formulation testing by contacting our sales team through the “Request a Quote” button. We are dedicated to providing all necessary documentation for your quality and regulatory processes.
Partner with an API Leader
Ensure the quality of your products by sourcing your Rifabutin API from an experienced and certified leader. Our team is ready to support your development and commercial supply needs.
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